Professor Sean Carroll

Professor of Sport, Health and Exercise Science

Faculty of Health Sciences

School of Life Sciences

s.carroll@hull.ac.uk

01482 463431

Lead, Research Excellence Framework (REF), Unit of Assessment, Sport and Exercise Science/ Programme Leader, Postgraduate Taught Programmes in Sport, Health and Exercise Science. 

Professor Sean Carroll re-joined the Department of Sport, Health and Exercise Science at the University of Hull in October 2011 and was Head of Department from 2012-16.

His personal and collaborative research has centred on both exercise / fitness epidemiology and integrative human exercise physiology and its relation to cardiovascular health and disease. He has a particular interest in lipidology / endocrinology and cardiovascular metabolism.

Professor Carroll was appointed Honorary Senior Research Fellow in the Academic Department of Cardiology, University of Hull. He is President and Fellow of the Royal Society of Medicine's Lipids, Metabolism and Vascular Risk academic section.

Research

Research Interests

  • The benefits of physical activity, exercise and fitness on cardiovascular disease and all-cause mortality outcomes in apparently healthy adults and patients with coronary artery disease

  • The role of cardiopulmonary exercise testing (CPET) for diagnosis and for risk stratification in coronary heart disease and chronic heart failure

  • The efficacy of structured, supervised exercise-based rehabilitation on risk factor modification, mortality, and morbidity in patients with cardiovascular disease

  • The assessment of cardiorespiratory fitness and individualised exercise prescription in healthy participants and those with chronic metabolic disorders

  • Lipids, metabolism and vascular risk. The effects of acute and chronic exercise on insulin resistance, post-prandial lipaemia, sub-clinical inflammation and the cardiovascular metabolic syndrome

  • Cardiovascular risk factor profiling and the non-invasive assessment of sub-clinical atherosclerosis

  • The benefits and limitations of physical activity, exercise on bone health in apparently healthy adults and elite athletic groups

  • Mechanisms of metabolic lipid disorders, including ectopic lipid storage and lipotoxicity; and treatment by lifestyle interventions, exercise and pharmaceutical therapies

  • Systematic review and meta-analysis

Research groups

  • The Exercise, Health and Sports Psychology research group, at the University of Hull

  • Member of the Steering Group, Metabolic Research Unit, Hull York Medical School, University of Hull

  • Development team member and scientific advisor to Heart Watch, Leeds community-based cardiac rehabilitation programme, Leeds Leisure Services, Leeds City Council. doi: 10.1136/openhrt-2017-000623. eCollection 2017

  • CARE CR-Cardiovascular and cardiorespiratory Adaptations to Routine Exercise-based Cardiac Rehabilitation: a study protocol for a community-based controlled study with criterion methods. Sport, Health and Exercise Science, City Healthcare Partnerships, Hull and East Riding & Academic Department of Cardiology, University of Hull. (with Dr S Nichols, Prof L Ingle, Prof A Clark) doi: 10.1136/bmjopen-2017-019216

  • Academic department of cardio-thoracic surgery at the Hull and East Yorkshire NHS Trust (with Dr J Hobkirk and Prof M Loubani)

Publications

Nichols S, Nation F, Goodman T, Clark A L, Carroll S, Ingle L, 'CARE CR-Cardiovascular and cardiorespiratory Adaptations to Routine Exercise-based Cardiac Rehabilitation: a study protocol for a community-based controlled study with criterion methods', British Medical Journal Open, 8:1 (2018)

Taylor C, Tsakirides C, Moxon J, Moxon J W, Dudfield M, Witte K, Ingle L, Carroll S, 'Exercise dose and all-cause mortality within extended cardiac rehabilitation: a cohort study', Open Heart, 4:2 (2017)

Taylor C, Tsakirides C, Moxon J, Moxon J W, Dudfield M, Witte K, Ingle L, Carroll S, 'Submaximal fitness and mortality risk in coronary heart disease: a retrospective cohort study of community-based exercise rehabilitation', British Medical Journal Open, 6:6 (2016)

Ingle L, Rigby A S, Sloan R, Carroll S, Goode K M, Cleland J G, Clark A L, 'Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure', Heart, 100: 10, pp 781-6 (2014)

Hamer M, Ingle L, Carroll S, Stamatakis E, 'Physical Activity and Cardiovascular Mortality Risk: Possible Protective Mechanisms?Medicine and Science in Sports and Exercise, 44:1, pp 84-8 (2012)

Teaching

Programmes taught on

Modules list

  • Clinical Exercise Testing, Programming and Prescription

  • Cardiovascular Disease, Treatments and Investigations

Research PhDs

Professor Carroll welcomes application's related to his areas of research focus.

Completed PhDs

  • A O’Doherty (2018) The Effects of acute exercise and nutritional interventions on postprandial lipid metabolism, University of Hull, (co-supervised with Prof Lee Ingle)

  • C Taylor (2017) Supervised exercise training, submaximal cardiorespiratory fitness and long-term all-cause mortality in participants undergoing community-based cardiac rehabilitation, University of Hull (co-supervised with Prof Lee Ingle)

  • E. Chalari (2017) The effect of intermittent exercise on biomarkers of oxidative stress, University of Hull (supervisory team member with Dr Mark Fogarty and Dr Huw Jones)

  • S. Nicholls (2015) The Cardiorespiratory and Vascular Adaptations to a Standard UK Exercise Based Cardiac Rehabilitation Programme, University of Hull (co-supervised with Prof Lee Ingle)

  • M G Mellis (2013) Physical activity, cardiorespiratory function and global cardiovascular disease risk in healthy young to middle-aged adults, Leeds Metropolitan University (co-supervised with Prof Lee Ingle)

  • R R Sloan (2012) The prognostic significance of cardiopulmonary exercise test variables in patients with suspected heart failure, Leeds Metropolitan University (collaborative research project with Dept of Academic Cardiology, University of Hull, co-supervised with Prof Lee Ingle)

  • J.P. Hobkirk (2011) Hypertriglyceridemia, small dense low-density lipoprotein and cardiometabolic risk stratification in paediatric obesity, Leeds Metropolitan University (co-supervised with Prof Rod King)

Current PhD supervisions 

  • Emma Whatley, PhD, 2014-date (co-supervised with Dr. J. Hobkirk) The relative energy deficiency syndrome and determinants of whole body and regional bone mineral density in female and male athletes     

  • Richard Page, PhD, 2014-date (co-supervised with Dr. J. Hobkirk) Physical activity/exercise, postprandial lipaemia and liver function in apparently healthy participants and patients with coronary heart disease

  • Fiona Nation, PhD, 2016-date (co-supervised with Dr. Simon Nichols) The Oxygen uptake efficiency plateau as a submaximal measure of cardiorespiratory fitness and adaptation to exercise training in healthy participants and patients with coronary heart disease

  • Dr Yama Haqzad, MD, 2015-date (co-supervised with Dr J Hobkirk and Prof M Loubani, Hull East Yorkshire NHS Trust) Lipogenic and oxidative gene profiles controlling myocardial energy metabolism and cardiac lipid accumulation in Type 2 diabetic and non-diabetic patients undergoing cardiac surgery

  • Dr Zaheer Tahir, MD, 2017-date (co-supervised with Dr J Hobkirk and Prof M Loubani, Hull East Yorkshire NHS Trust) Dicholoroacetate and cardiac energy metabolism in response to ischaemia and re-perfusion

Professional highlights

Academic qualifications

  • BA (Hons), Leeds Metropolitan University

  • PhD by published works, Physical activity, exercise and the cardiometabolic syndrome in middle-aged men, Leeds Metropolitan University

External roles

Member, British Association of Sport and Exercise Science.

Regularly reviewed manuscripts for the most prominent journals in the disciplinary area of integrative physiology, cardiology and sport and exercise science, including British Medical Journal, Journal of American Medical Association, Paediatric and Adolescent Medicine, International Journal of Obesity and Related Metabolic Disorders, Expert Review in Cardiovascular Therapy, BMC Medical Genetics, Journal of the Canadian Medical Association, British Journal of Sports Medicine, Medicine and Science in Sports and Exercise, International Journal of Sports Medicine, Applied Physiology, Nutrition and Metabolism, European Journal of Sports Science and Nutrition, Metabolism and Cardiovascular Disease.

Refereed fellowship applications for the Medical Research Council (MRC), and project grants for Irish Health Board, Medical Research Council and BBSRC.

Invited to present at a number of international conferences, including those of the European Society of Cardiology, International Diabetes Federation, European College of Sports Science. In 2017, invited to speak at the Royal Society of Medicine.

Accepted invitations to present at a number of national conferences including British Association of Sports and Exercise Sciences, British Cardiovascular Society / British Association of Cardiovascular Prevention and Rehabilitation.

First or senior author on a number of multidisciplinary high impact and widely-cited journal articles, including Sports Medicine, Medicine and Science in Sports and Exercise, British Journal of Sports Medicine, British Medical Journal Open, International Journal of Sports Medicine, Scandinavian Journal of Medicine and Science in Sports, European Journal of Nutrition, Metabolic Syndrome and Related Disorders, Osteoporosis International, Bone, Applied Physiology Nutrition and Metabolism, amongst others.

Published work on the effects of exercise on the metabolic syndrome and bone health were cited in the Physical Activity Guidelines Advisory Committee Report (2008), for the Secretary of Health and Human Services, United States.

Received external funding from Leeds Leisure Services, Covance Ltd. Independent Clinical Trials Company, Astra Zeneca Pharmaceuticals, Hull and East Yorkshire NHS Trust, Leeds North West PCT, and the Hull and East Riding Cardiac Trust Fund.

Examined MRes, MPhil, and PhD theses at the universities of Loughborough, Warwick, Manchester, Hull, Leeds Beckett, and Catholic University of Australia.

Previously appointed external programme examiner for BSc and MSc sport and exercise science pathways at the universities of Teeside, Abertay, Kingston University and Sheffield Hallam University. Previously appointed as external programme validation panel member for sport and exercise science pathways at the Universities of Leeds Metropolitan, Lancaster and Hull.

Selected national and international collaborators;

  • Prof Mahmoud Loubani, Consultant Cardiothoracic Surgeon, Hull and East Yorkshire NHS Trust

  • Dr Handrean Soran, Consultant Physician, Head of Lipoprotein Research laboratory, Cardiovascular Research Group, University of Manchester

  • Dr Cordula Stover, Senior Lecturer in Immunology Infection and Inflammation, University of Leicester

  • Professor Katherine Cianflone, Former Canadian Chair in Adipose Tissue Biology, Laval University, Canada

Awards and accolades

  • Honorary Senior Fellow, Postgraduate Medical Institute, Academic Department of Cardiology, University of Hull, January 2011

  • Cardiographer Award, Cardiology, Department of Cardiovascular Studies, University of Leeds Medical School / United Leeds Teaching Hospitals Trust 1988

  • Research Excellence Framework 2014 Lead, Unit 26, Sport and Exercise Sciences, Leisure and Tourism, University of Hull

Professional highlights

  • President and Council member, Lipids, Metabolism and Vascular Risk section, Royal Society of Medicine

  • Senior Associate / Fellow, Royal Society of Medicine

  • Head of Department, Sport, Heath and Exercise Science, University of Hull, November 2012- 2016