‘Going for gold’ in the fight against HIV
Last updated on 7/1/2013 Print this page
27 September 2012
University of Hull research into how HIV infection could be
prevented is the first to be published under a new scheme to make
academic work open to all.
The research paper by Dr Steve Archibald et al,
published recently in Dalton Transactions, is now freely
available online as part of the Royal Society of Chemistry (RSC)
‘Gold for Gold’ scheme.
< Steve Archibald and
Gold for Gold rewards UK subscribers to the RSC Gold Package with a
number of free credits to publish their work via RSC’s open access
option. This means that the RSC will pay the fee for the work to be
published, rather than academics or their universities.
Dr Tim Prior, Chair of the Chemistry Research
Committee at Hull put forward the paper for the RSC scheme. He
said: “We are delighted to be the first to publish our work under
Gold for Gold. This paper potentially has real applications around
the world and it is wonderful that people anywhere will now be able
to read it online for free.”
The research paper examines how to block
communication between cells by inhibiting chemokine receptors,
which are natural proteins in the human body that form part of
the cell’s signalling process and are linked to viral
infection and other diseases. In the Hull study, scientists
developed and tested nickel-containing compounds that block
receptor communication and inhibit HIV infection.
Dr Archibald said: “This research shows the
role that metal containing compounds can have in medicinal
chemistry. There is a need for new, more powerful drugs to treat
diseases and we have demonstrated an extremely high potency in
blocking both a receptor signalling process and infection by HIV. I
hope this work will inspire other researchers to test a wider
variety of compounds against protein targets in drug
Dr James Milne, Managing Director for RSC
Publishing, said: “We are delighted to have published this timely
and impactful paper as the first ‘Gold for Gold’ article. The
initiative has been received very warmly by librarians and
researchers alike, and aims to support the chemical science
community during the transition to Gold Open Access publishing, as
sought by the Research Councils”.
Read the paper entitled ‘CXCR4
chemokine receptor antagonists: nickel(II) complexes of
configurationally restricted macrocycles’ for free.