Chemistry
School of Mathematics & Physical Sciences

Prof Mark Lorch

BSc (Warwick), PhD (Bristol)

Mark Lorch

Associate Dean, Engagement
Professor of Science Communication

Department of Chemistry

  • Profile
  • Teaching
  • Research
  • Key publications
  • Public engagement
  • Showreel

Profile

Mark got his BSc in Biochemistry from the University of Warwick. He then completed doctoral studies and a post-doc on protein folding at the University of Bristol. Next Mark moved to Goethe University in Frankfurt where he acquired (some of) the tricks of solid state NMR. In 2006 he took up an RCUK fellowship at the University of Hull, as a joint appointment between the departments of Chemistry and Biology. He was promoted to Senior Lecturer in in 2013 and Professor in 2016.

In 2014 Mark was appointed Associate Dean for Engagement for the Faculty of Science and Engineering. Within this role he oversees the faculty’s international partnerships, student recruitment and public engagement activities. Mark is also the Director of the Hull Science Festival on sits on University Senate and Council.

Mark is committed to science communication. He hosts the Beverley Science Cafe, holds regular family learning science workshops and has even been spotted doing kitchen chemistry in Hull's shopping centres. He was a UK national finalist of Famelab and has since appeared on BBC’s Coast, BBC Radio 4’s You and  Yours, US public service radio and numerous regional radio and TV shows. Mark also has a talent for blogging and science journalism. He now blogs at Chemistry Blog for the chemical community and for everyone else in places such as The Guardian and The Conversation. His prose has also appeared in Nature Chemistry, The Hindu Times, Scientific American and Ars Technica.

Teaching

Lectures courses

  • Foundation Science
  • Chemistry in Context, Nature's robots
  • Advanced NMR spectroscopy
  • Biological macromolecules, lipids and membranes
  • Chemistry for Biologists, NMR
  • Public Engagement and Science Communication

Laboratory classes

  • Foundation Science

Research

Research theme: Biological Chemistry
Research group: Biological Chemistry and Lipids Research Interest

Research interests

  • Drug/lipid interactions
  • Protein/membrane interactions in Amyloid disease
  • Use of sporopollonin exines as surfactants and drug delivery devices

My research focuses on the interactions that occur at and in lipid membranes.

I am particularly interested in how drugs penertrate membranes on their way to their target site and also what affect the drug molecules have on the phase behaviour of lipid membranes.

The Alzheimer's peptide beta -amyloid is also the subject of my research. Studying the interactions between this peptide and cell membranes may help us understand its involvement in Alzheimer's disease.

As a sideline I've also got interested in using plant spores for biotech applications. It turns out that the exine shells around spores can be used as amazingly versatile microencapsulation devices with applications from drug delivery to taste masking and oil sequestration.

Much of my research uses solid state NMR to probe the structure an function of these systems.

Key Publications

Recent and representative publications

Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer M.De Poli, W.Zawodny, O.Quinonero, M.Lorch, S.JWebb, J.Clayden. Science. (2016) doi: 10.1126/science.aad8352

Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a 13C-labeled Signal Peptide Bound to Lipid-Reconstituted SEC Translocon, L. Reggie, J.J. Lopex, I. Collinson, C. Glaubitz and M. Lorch J. Am. Chem. Soc., 2011 133(47) 19084-19086. doi: 10.1021/ja209378h

Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers, R. Batchelor, C.J. Windle, S. Buchoux and M. Lorch J. Biol. Chem., 2010, 285, 41402-41411. doi: 10.1074/jbc.M110.155176

Access to a primary aminosporopollenin solid support from plant spores, S. Barrier, A. Lobbert, A. J. Boasman, A. N. Boa, M. Lorch, S. L. Atkin, and G. Mackenzie, Green Chemistry, 2010, 12, 234-40. doi: 10.1039/b913215e

Full publication list

Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer M.De Poli, W.Zawodny, O.Quinonero, M.Lorch, S.JWebb, J.Clayden. Science. (2016) doi: 10.1126/science.aad8352

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions. B.P.Burke, N.Baghdadi, A.E.Kownacka, S.Nigam, G.S.Clemente,  M.M.Al-Yassiry, J.Domarkas, M.Lorch, M.Pickles, P.Gibbs, R.Tripier, C.Cawthorne, S.J.Archibald,. Nanoscale. (2015) doi: 10.1126/science.aad8352

Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach. F. Cheng, M. Lorch, S.M. Sajedin, S.M. Kelly & A. Kornherr. ChemSusChem. (2013) 6(8)1392-1399.

Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking A. Diego-Taboada, L. Maillet, Banoub, J.H.,  M. Lorch,  A.S. Rigby , A.N. Boa, S.L. Atkin, S.T. Beckett and G. MacKenzie. J. Mats. Chem. B. 2013 1(5) 707-713.

A clerical error provides a unique opportunity to study the effect of previously seen exam questions on exam results. T.J. Prior and M. Lorch New Directions 2012 8, 49-52 DOI: 10.11120/ndir.2012.00080049

Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores. J. Mats. Chem. A. Diego-Taboada, P. Cousson, E. Raynaud, Huang, Y.,  M. Lorch, B.P. Binks, Y. Queneau, A.N. Boa, S.L. Atkin, S.T. Beckett and G. MacKenzie. 2012 22(19) 9767-9773

Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a 13C-labeled Signal Peptide Bound to Lipid-Reconstituted SEC Translocon. L. Reggie, J.J. Lopex, I. Collinson, C. Glaubitz and M. Lorch. J. Am. Chem. Soc., 2011 133(47) 19084-19086. doi: 10.1021/ja209378h

Stabilizing membrane proteins in detergent and lipid systems in Robinson A.S. (eds) Production of membrane proteins: Stratgies for Expression and Isolation, New York,: Wiley 361-383

Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers, R. Batchelor, C.J. Windle, S. Buchoux and M. Lorch J. Biol. Chem., 2010, 285, 41402-41411. doi: 10.1074/jbc.M110.155176

Access to a primary aminosporopollenin solid support from plant spores, S. Barrier, A. Lobbert, A. J. Boasman, A. N. Boa, M. Lorch, S. L. Atkin, and G. Mackenzie, Green Chemistry, 2010, 12, 234-40. doi: 10.1039/b913215e

MRI contrast agent delivery using spore capsules: controlled release in blood plasma, M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie, and S. J. Archibald, Chem. Commun., 2009, 6442-4. doi: 10.1039/b909551a

Lipid Unsaturation and Membrane Protein Has an Enormous Effect on the Gel Phase Hysteresis of Mixed Phospholipids, J. W. Jones, L. Lue, M. Lorch, A. Saiani, A. Tahlawi, and G. J. Tiddy, J. Cosmet. Sci., 2009, 60, 393-4. doi:

Phosphatidylglycerol lipids enhance folding of an alpha helical membrane protein, A. M. Seddon, M. Lorch, O. Ces, R. H. Templer, F. Macrae, and P. J. Booth, J. Mol. Biol., 2008, 380, 548-56. doi: 10.1016/j.jmb.2008.05.001

Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR, N. Pfleger, M. Lorch, A. C. Woerner, S. Shastri, and C. Glaubitz, J. Biomol. NMR, 2008, 40, 15-21. doi: 10.1007/s10858-007-9203-5

Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes, J. J. Lopez and M. Lorch, J. Biol. Chem., 2008, 283, 7813-22. doi: 10.1074/jbc.M707480200

Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence, D. Basting, M. Lorch, I. Lehner, and C. Glaubitz, FASEB J., 2008, 22, 365-73. doi: 10.1096/fj.07-9162com

Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors, S. C. Jha, M. Lorch, R. A. Lewis, S. J. Archibald, and R. W. Boyle, Org. Biomol. Chem., 2007, 5, 1970-4. doi: 10.1039/b703646a

Crystal structure of 4-hexyl-4 '-hydroxyazobenzene isopropanol hemisolvate, C18H22N2O center dot 1/2C(3)H(8)O, H. R. Nasiri, M. Bolte, M. Lorch, and H. Schwalbe, Z. Krist.-New Cryst. Struct., 2006, 221, 219-20. doi: 10.1524/ncrs.2006.0046

Kinetics of an individual transmembrane helix during bacteriorhodopsin folding, E. L. R. Compton, N. A. Farmer, M. Lorch, J. M. Mason, K. M. Moreton, and P. J. Booth, J. Mol. Biol., 2006, 357, 325-38. doi: 10.1016/j.jmb.2005.12.042

Investigating transport proteins by solid state NMR, D. Basting, I. Lehner, M. Lorch, and C. Glaubitz, Naunyn-Schmiedebergs Arch. Pharmacol., 2006, 372, 451-64. doi: 10.1007/s00210-006-0039-4

A kinetic study of the folding of Diacylglycerol Kinase (DAGK), A. M. Seddon, M. Lorch, and P. J. Booth, Biophys. J., 2005, 88, 49A-A. doi:

NMR and fluorescence spectroscopy approaches to secondary and primary active multidrug efflux pumps, M. Lorch, I. Lehner, A. Siarheyeva, D. Basting, N. Pfleger, T. Manolikas, and C. Glaubitz, Biochem. Soc. Trans., 2005, 33, 873-7. doi:

How to prepare membrane proteins for solid-state NMR: A case study on the cc-helical integral membrane protein diacylglycerol kinase from E-coli, M. Lorch, S. Fahem, C. Kaiser, I. Weber, A. J. Mason, J. U. Bowie, and C. Glaubitz, Chembiochem, 2005, 6, 1693-700. doi: 10.1002/cbic.200500054

Translocation of the cell - penetrating Tat peptide across artificial bilayers and into living cells, P. Curnow, H. Mellor, D. J. Stephens, M. Lorch, and P. J. Booth, in 'Lipids, Rafts and Traffic', ed. R. A. J. H. N. M. McIlhinney, London, 2005.

A kinetic study of the folding of diacylglycerol kinase, A. M. Seddon, M. Lorch, and P. J. Booth, Biophys. J., 2004, 86, 255A-A. doi:

Residue specific isotope labelling and first solid-state NMR experiments on the L-lactis ABC multidrug transport LmrA, a functional homologue of the human P-glycoprotein, A. J. Mason, A. Siarheyeva, M. Lorch, H. van Veen, and C. Glaubitz, Biophys. J., 2004, 86, 99A-100A. doi:

Amino acid type selective isotope labelling of the multidrug ABC transporter LmrA for solid-state NMR studies, A. J. Mason, A. Siarheyeva, W. Haase, M. Lorch, H. van Veen, and C. Glaubitz, FEBS Lett., 2004, 568, 117-21. doi: 10.1016/j.febslet.2004.05.016

Solid state NMR studies on the integral membrane protein diacylglyerol kinase from E. coli, M. Lorch, A. J. Mason, and C. Glaubitz, Biophys. J., 2004, 86, 99A-A. doi:

Insertion kinetics of a denatured alpha helical membrane protein into phospholipid bilayer vesicles, M. Lorch and P. J. Booth, J. Mol. Biol., 2004, 344, 1109-21. doi: 10.1016/j.jmb.2004.09.090

The reconstitution and activity of the small multidrug transporter EmrE is modulated by non-bilayer lipid composition, P. Curnow, M. Lorch, K. Charalambous, and P. J. Booth, J. Mol. Biol., 2004, 343, 213-22. doi: 10.1016/j.jmb.2004.08.032

Effects of lipid vesicle composition on DGK refolding, M. Lorch and P. J. Booth, Biophys. J., 2002, 82, 1700. doi:

In vitro studies of membrane protein folding, P. J. Booth, R. H. Templer, W. Meijberg, S. J. Allen, A. R. Curran, and M. Lorch, Crit. Rev. Biochem. Mol. Biol., 2001, 36, 501-603. doi:

Progressive stabilization of intermediate and transition states in protein folding reactions by introducing surface hydrophobic residues, D. Poso, R. B. Sessions, M. Lorch, and A. R. Clarke, J. Biol. Chem., 2000, 275, 35723-6. doi:

Effects of mutations on the thermodynamics of a protein folding reaction: Implications for the mechanism of formation of the intermediate and transition states, M. Lorch, J. M. Mason, R. B. Sessions, and A. R. Clarke, Biochemistry, 2000, 39, 3480-5. doi:

Effects of core mutations on the folding of a beta-sheet protein: Implications for backbone organization in the I-State, M. Lorch, J. M. Mason, A. R. Clarke, and M. J. Parker, Biochemistry, 1999, 38, 1377-85. doi:

Thermodynamic properties of transient intermediates and transition states in the folding of two contrasting protein structures, M. J. Parker, M. Lorch, R. B. Sessions, and A. R. Clarke, Biochemistry, 1998, 37, 2538-45. doi:

Acquisition of native beta-strand topology during the rapid collapse phase of protein folding, M. J. Parker, C. E. Dempsey, M. Lorch, and A. R. Clarke, Biochemistry, 1997, 36, 13396-405. doi:

Structure of a kinetic protein folding intermediate by equilibrium amide exchange, L. L. P. Hosszu, C. J. Craven, M. J. Parker, M. Lorch, J. Spencer, A. R. Clarke, and J. P. Waltho, Nature Structural Biology, 1997, 4, 801-4. doi:

Public engagement

Selected Public Engagement Activities

Regular Magazine Columns

 Chemistry columnist for the New Humanist

 Q&A expert panel for BBC Focus

Selected Magazine and Newspaper articles

- A wish for plain language, Evonik, April 2016

- Chemophobia and chemists' construct. RSC News, August 2015

- Why do people hate the word ‘Chemicals’. Readers Digest. Summer 2015.

- Crowd sourcing chemistry, Nature Chemistry , 2013 5:pp 359

- The Geeks are Coming. June 2012. Civil Service World. pp. 22.

- Lorch, M. Chemistry and the community. August 2011 Commerce and Industry 17(3), pp. 25.

High impact blogs and webpages

 Regular contributor to The Guardian. 15 posts since October 2012. Available at  http://www.theguardian.com/profile/mark-lorch

Regular contributor to The Conversation. 27 posts articles since May 2013. Accumulating over 8 million reads. Available at https://theconversation.com/profiles/mark-lorch-91662/articles

Consumer Confusion Part 1 – Bio and Non-Bio washing powders. You and Yours. 3 December 2012. Available at: http://www.bbc.co.uk/programmes/b01p3hnz [Accessed 25th January, 2015]

Chemistry-blog [blog] Staff blogger since March 2012. Available at: http://www.chemistry-blog.com/. [Accessed 25th January, 2015]

Radio

1) Lorch, M. ‘Naked Scientist Christmas Party’ BBC Radio 5 live, 23:00 hrs 25th December 2014. ABC National radio, Australia, 26th. 10:00 hrs December 2015

2) Lorch, M ‘5 Live Drive’. BBC Radio 5 live. 16:00 hrs. 25th January 2014

3) Lorch, M. ‘Four thought’ BBC Radio 4. 27th November 2013. 20:45 hrs. http://www.bbc.co.uk/radio/player/b03jdw70 [Accessed 25th January, 2015]

4) Lorch, M. ‘Marketplace Tech’. American Public Media.  27 March 2013. Varies broadcast times across USA.  http://www.marketplace.org/topics/tech/incredible-history-lcd-flat-screen-tv[accessed 25th  January 2015].

5) Lorch, M. ‘You and Yours’. BBC Radio 4. 3 December 2012. 12:00 hrs  www.bbc.co.uk/programmes/b01p3hnz  [accessed 25th  January 2015].

Over 20 appearances on regional radio since 2012.

Television

1) Lorch, M. Nigel Slater’s Great British Biscuits BBC4,18th December 2013, 21:00 hrs

2) Lorch, M. Some Scientists with Jokes, BBC 4 24th July. 22:00 hrs

3) Lorch M. Coast. Series 8 Episode 2, ‘The Worker’s Coast’ BBC 2. 10 April 2013. 20:00 hrs  

4) Lorch M. ‘Look North’- Yorkshire, BBC 1. 23 March 2013. 18:30 hrs 

5) Lorch M. ‘Points of View’  Commenting on James May’s Thing You Need to Know About Chemistry. BBC 2. 7 October 2012. 16:40hrs

6) Lorch M. ‘Calendar TV‘   ITV. 14th June 2011. 18:30 hrs.

Accolades

Named in ’20 chemists worth following on Twitter’. C&EN Magazine 92(39) 29th September, 2014 http://cen.acs.org/articles/92/i39/20-Chemists-Worth-Following-Twitter.html [Accessed 25th January, 2015]

Named in ‘Top blog posts of 2014’ 19th December 2014 Nature Chemistry http://blogs.nature.com/thescepticalchymist/2014/12/the-top-blog-posts-of-2014.html [Accessed 25th January, 2015]

Named in ‘Top 10 chemistry blogs posts of 2013’ 11th December 2013 Nature Chemistry http://blogs.nature.com/thescepticalchymist/2013/12/the-top-10-chemistry-blog-posts-of-2013.html [Accessed 25th January, 2015]

Famelab 2012 National Finalist. Royal Institution. March 2012.

Most read author, out of over 30,000 academics, on The Conversation network

Showreel

Select videos

Radio interviews

Mark Lorch: Chemiphobia

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