Department of Chemistry

Dr Mark Lorch

BSc (Warwick), PhD (Bristol)

Mark Lorch

Senior Lecturer in Biological Chemistry

Department of Chemistry

  • Profile
  • Teaching
  • Research
  • Key publications
  • Public engagement
  • Showreel

Profile

Mark got his BSc in Biochemistry from the University of Warwick, he then completed doctoral studies and a post-doc on protein folding at the University of Bristol. Next Mark moved to Goethe University in Frankfurt where he aquired(some of) the tricks of solid state NMR, but singularly failed to learn to speak German. In 2006 he took up an RCUK fellowship at the University of Hull, as a joint appointment between the departments of Chemistry and Biology. He has since been promoted to senior lecturer in the Chemistry Department. So nows he's a fully fledged chemist (with a Royal Society of Chemistry membership to prove it). He still likes to prattle on about protein folding, but mainly researches lipid/protein/drug intereactions with a sideline in spores.

Mark is committed to science communication, he hosts the Beverley Science Cafe, holds regular family learning science workshops and has even been spotted doing kitchen chemistry in Hull's shopping centres. He was a UK national finalist of Famelab and has since appeared on BBC’s Coast, BBC Radio 4’s You and  Yours, US public service radio and numerous  regional radio and TV shows.

Much to his surprise Mark has discovered a talent for blogging and science journalsim. His Mum can’t quite believe it either, because frankly Mark would barely writea thing at school and can’t spell four tofee. He now blogs at http://www.chemistry-blog.com/ for the chemical community and at Try this at home for everyone else. The Guardian also seems to like his stuff and so does The Conversation. His prose has also appeared in Nature Chemistry, The Hindu Times and Ars Technica. And he writes a regular column called Sixty Second Science for the Hull Daily Mail.

Departmental and University roles

  • Student Recruitment Director
  • School Liaison Officer
  • Faculty Public Engagement Director

Teaching

Lectures courses

  • Foundation Science
  • Chemistry in Context, Nature's robots
  • Advanced NMR spectroscopy
  • Biological macromolecules, lipids and membranes
  • Chemistry for Biologists, NMR
  • Public Engagement and Science Communication

Laboratory classes

  • Foundation Science

Research

Research theme: Biological Chemistry
Research group: Biological Chemistry and Lipids Research Interest

Research interests

  • Drug/lipid interactions
  • Protein/membrane interactions in Amyloid disease
  • Use of sporopollonin exines as surfactants and drug delivery devices

My research focuses on the interactions that occur at and in lipid membranes.

I am particularly interested in how drugs penertrate membranes on their way to their target site and also what affect the drug molecules have on the phase behaviour of lipid membranes.

The Alzeihmer's peptide beta -amyloid is also the subject of my research. Studying the interactions between this peptide and cell membranes may help us understand its involvment in Alzeihmer's disease.

As a sideline I've also got interested in using plant spores for biotech applications. It turns out that the exine shells around spores can be used as amazingly versatile microencapsulation devices with applications from drug delivery to taste masking and oil sequestration.

Much of my research uses solid state NMR to probe the structure an function of these systems.

Key Publications

Recent and representative publications

Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a 13C-labeled Signal Peptide Bound to Lipid-Reconstituted SEC Translocon, L. Reggie, J.J. Lopex, I. Collinson, C. Glaubitz and M. Lorch J. Am. Chem. Soc., 2011 133(47) 19084-19086. doi: 10.1021/ja209378h

Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers, R. Batchelor, C.J. Windle, S. Buchoux and M. Lorch J. Biol. Chem., 2010, 285, 41402-41411. doi: 10.1074/jbc.M110.155176

Access to a primary aminosporopollenin solid support from plant spores, S. Barrier, A. Lobbert, A. J. Boasman, A. N. Boa, M. Lorch, S. L. Atkin, and G. Mackenzie, Green Chemistry, 2010, 12, 234-40. doi: 10.1039/b913215e

MRI contrast agent delivery using spore capsules: controlled release in blood plasma, M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie, and S. J. Archibald, Chem. Commun., 2009, 6442-4. doi: 10.1039/b909551a

Full publication list

Whiter, brighter, and more stable cellulose paper coated with TiO 2/SiO2 core/shell nanoparticles using a layer-by-layer approach. F. Cheng, M. Lorch, S.M. Sajedin, S.M. Kelly & A. Kornherr. ChemSusChem. (2013) 6(8)1392-1399.

Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking A. Diego-Taboada, L. Maillet, Banoub, J.H.,  M. Lorch,  A.S. Rigby , A.N. Boa, S.L. Atkin, S.T. Beckett and G. MacKenzie. J. Mats. Chem. B. 2013 1(5) 707-713.

A clerical error provides a unique opportunity to study the effect of previously seen exam questions on exam results. T.J. Prior and M. Lorch New Directions 2012 8, 49-52 DOI: 10.11120/ndir.2012.00080049

Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores. J. Mats. Chem. A. Diego-Taboada, P. Cousson, E. Raynaud, Huang, Y.,  M. Lorch, B.P. Binks, Y. Queneau, A.N. Boa, S.L. Atkin, S.T. Beckett and G. MacKenzie. 2012 22(19) 9767-9773

Dynamic Nuclear Polarization-Enhanced Solid-State NMR of a 13C-labeled Signal Peptide Bound to Lipid-Reconstituted SEC Translocon. L. Reggie, J.J. Lopex, I. Collinson, C. Glaubitz and M. Lorch. J. Am. Chem. Soc., 2011 133(47) 19084-19086. doi: 10.1021/ja209378h

Stabilizing membrane proteins in detergent and lipid systems in Robinson A.S. (eds) Production of membrane proteins: Stratgies for Expression and Isolation, New York,: Wiley 361-383

Cholesterol and lipid phases influence the interactions between serotonin receptor agonists and lipid bilayers, R. Batchelor, C.J. Windle, S. Buchoux and M. Lorch J. Biol. Chem., 2010, 285, 41402-41411. doi: 10.1074/jbc.M110.155176

Access to a primary aminosporopollenin solid support from plant spores, S. Barrier, A. Lobbert, A. J. Boasman, A. N. Boa, M. Lorch, S. L. Atkin, and G. Mackenzie, Green Chemistry, 2010, 12, 234-40. doi: 10.1039/b913215e

MRI contrast agent delivery using spore capsules: controlled release in blood plasma, M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie, and S. J. Archibald, Chem. Commun., 2009, 6442-4. doi: 10.1039/b909551a

Lipid Unsaturation and Membrane Protein Has an Enormous Effect on the Gel Phase Hysteresis of Mixed Phospholipids, J. W. Jones, L. Lue, M. Lorch, A. Saiani, A. Tahlawi, and G. J. Tiddy, J. Cosmet. Sci., 2009, 60, 393-4. doi:

Phosphatidylglycerol lipids enhance folding of an alpha helical membrane protein, A. M. Seddon, M. Lorch, O. Ces, R. H. Templer, F. Macrae, and P. J. Booth, J. Mol. Biol., 2008, 380, 548-56. doi: 10.1016/j.jmb.2008.05.001

Characterisation of Schiff base and chromophore in green proteorhodopsin by solid-state NMR, N. Pfleger, M. Lorch, A. C. Woerner, S. Shastri, and C. Glaubitz, J. Biomol. NMR, 2008, 40, 15-21. doi: 10.1007/s10858-007-9203-5

Location and orientation of serotonin receptor 1a agonists in model and complex lipid membranes, J. J. Lopez and M. Lorch, J. Biol. Chem., 2008, 283, 7813-22. doi: 10.1074/jbc.M707480200

Transport cycle intermediate in small multidrug resistance protein is revealed by substrate fluorescence, D. Basting, M. Lorch, I. Lehner, and C. Glaubitz, FASEB J., 2008, 22, 365-73. doi: 10.1096/fj.07-9162com

Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors, S. C. Jha, M. Lorch, R. A. Lewis, S. J. Archibald, and R. W. Boyle, Org. Biomol. Chem., 2007, 5, 1970-4. doi: 10.1039/b703646a

Crystal structure of 4-hexyl-4 '-hydroxyazobenzene isopropanol hemisolvate, C18H22N2O center dot 1/2C(3)H(8)O, H. R. Nasiri, M. Bolte, M. Lorch, and H. Schwalbe, Z. Krist.-New Cryst. Struct., 2006, 221, 219-20. doi: 10.1524/ncrs.2006.0046

Kinetics of an individual transmembrane helix during bacteriorhodopsin folding, E. L. R. Compton, N. A. Farmer, M. Lorch, J. M. Mason, K. M. Moreton, and P. J. Booth, J. Mol. Biol., 2006, 357, 325-38. doi: 10.1016/j.jmb.2005.12.042

Investigating transport proteins by solid state NMR, D. Basting, I. Lehner, M. Lorch, and C. Glaubitz, Naunyn-Schmiedebergs Arch. Pharmacol., 2006, 372, 451-64. doi: 10.1007/s00210-006-0039-4

A kinetic study of the folding of Diacylglycerol Kinase (DAGK), A. M. Seddon, M. Lorch, and P. J. Booth, Biophys. J., 2005, 88, 49A-A. doi:

NMR and fluorescence spectroscopy approaches to secondary and primary active multidrug efflux pumps, M. Lorch, I. Lehner, A. Siarheyeva, D. Basting, N. Pfleger, T. Manolikas, and C. Glaubitz, Biochem. Soc. Trans., 2005, 33, 873-7. doi:

How to prepare membrane proteins for solid-state NMR: A case study on the cc-helical integral membrane protein diacylglycerol kinase from E-coli, M. Lorch, S. Fahem, C. Kaiser, I. Weber, A. J. Mason, J. U. Bowie, and C. Glaubitz, Chembiochem, 2005, 6, 1693-700. doi: 10.1002/cbic.200500054

Translocation of the cell - penetrating Tat peptide across artificial bilayers and into living cells, P. Curnow, H. Mellor, D. J. Stephens, M. Lorch, and P. J. Booth, in 'Lipids, Rafts and Traffic', ed. R. A. J. H. N. M. McIlhinney, London, 2005.

A kinetic study of the folding of diacylglycerol kinase, A. M. Seddon, M. Lorch, and P. J. Booth, Biophys. J., 2004, 86, 255A-A. doi:

Residue specific isotope labelling and first solid-state NMR experiments on the L-lactis ABC multidrug transport LmrA, a functional homologue of the human P-glycoprotein, A. J. Mason, A. Siarheyeva, M. Lorch, H. van Veen, and C. Glaubitz, Biophys. J., 2004, 86, 99A-100A. doi:

Amino acid type selective isotope labelling of the multidrug ABC transporter LmrA for solid-state NMR studies, A. J. Mason, A. Siarheyeva, W. Haase, M. Lorch, H. van Veen, and C. Glaubitz, FEBS Lett., 2004, 568, 117-21. doi: 10.1016/j.febslet.2004.05.016

Solid state NMR studies on the integral membrane protein diacylglyerol kinase from E. coli, M. Lorch, A. J. Mason, and C. Glaubitz, Biophys. J., 2004, 86, 99A-A. doi:

Insertion kinetics of a denatured alpha helical membrane protein into phospholipid bilayer vesicles, M. Lorch and P. J. Booth, J. Mol. Biol., 2004, 344, 1109-21. doi: 10.1016/j.jmb.2004.09.090

The reconstitution and activity of the small multidrug transporter EmrE is modulated by non-bilayer lipid composition, P. Curnow, M. Lorch, K. Charalambous, and P. J. Booth, J. Mol. Biol., 2004, 343, 213-22. doi: 10.1016/j.jmb.2004.08.032

Effects of lipid vesicle composition on DGK refolding, M. Lorch and P. J. Booth, Biophys. J., 2002, 82, 1700. doi:

In vitro studies of membrane protein folding, P. J. Booth, R. H. Templer, W. Meijberg, S. J. Allen, A. R. Curran, and M. Lorch, Crit. Rev. Biochem. Mol. Biol., 2001, 36, 501-603. doi:

Progressive stabilization of intermediate and transition states in protein folding reactions by introducing surface hydrophobic residues, D. Poso, R. B. Sessions, M. Lorch, and A. R. Clarke, J. Biol. Chem., 2000, 275, 35723-6. doi:

Effects of mutations on the thermodynamics of a protein folding reaction: Implications for the mechanism of formation of the intermediate and transition states, M. Lorch, J. M. Mason, R. B. Sessions, and A. R. Clarke, Biochemistry, 2000, 39, 3480-5. doi:

Effects of core mutations on the folding of a beta-sheet protein: Implications for backbone organization in the I-State, M. Lorch, J. M. Mason, A. R. Clarke, and M. J. Parker, Biochemistry, 1999, 38, 1377-85. doi:

Thermodynamic properties of transient intermediates and transition states in the folding of two contrasting protein structures, M. J. Parker, M. Lorch, R. B. Sessions, and A. R. Clarke, Biochemistry, 1998, 37, 2538-45. doi:

Acquisition of native beta-strand topology during the rapid collapse phase of protein folding, M. J. Parker, C. E. Dempsey, M. Lorch, and A. R. Clarke, Biochemistry, 1997, 36, 13396-405. doi:

Structure of a kinetic protein folding intermediate by equilibrium amide exchange, L. L. P. Hosszu, C. J. Craven, M. J. Parker, M. Lorch, J. Spencer, A. R. Clarke, and J. P. Waltho, Nature Structural Biology, 1997, 4, 801-4. doi:

Public engagement

Selected Public Engagement Activities

CREST studentships organiser. 2013

Cheltenham Science festival. Show for primary schools titled When the Monkey met the Ipad. June 2013

Co-authored science based play Investigation Haunted House. Delivered, with accompanying workshop, to 19 primary schools in Yorkshire, Lancashire and the Bradford Science Festival.  2012-13

Chemistry Christmas Lectures for the public and schools. 2011 & 2012

Established Beverley Science Cafe and Wyke Science Cafes. 2011- present

Delivery of activities during STEM week. 2010- present

Over 60 lectures, shows, demonstrations and workshops for primary schools, secondary schools, colleges and families since 2010

Invited/competitive public engagement activities

York festival of ideas. North and South, Magnets and Medicine. York. June 2013

TEDxHull, Science Busking, Hull Truck Theatre. April 2013

Bradford Science Festival. Kitchen Chemistry. Bradford University October 2012.

Famelab 2012 National Finalist. Royal Institution. March 2012.

British Science Association Festival, Bradford. Kitchen Chemistry. September 2011

Royal Society Scientist/MP pairing scheme. Palace of Westminster, November 2008

Media Contributions

Magazine and newspaper articles

Lorch, M. Silver bullets kill bacteria, not werewolves or witches. 20 June 2013. The Hindu.

Lorch, M. Sixty Second Science. From May 2013. Monthly Column in Hull Daily Mail.

Lorch, M. Hull’s Culture of Science. 25 June 2012. Hull Daily Mail. pp. 15.

Lorch, M. The Geeks are Coming. June 2012. Civil Service World. pp. 22.

Lorch, M. Chemistry and the community. August 2011 Commerce and Industry 17(3), pp. 25.

Lorch, M. Research and Innovations That Touch Peoples’ Everyday Lives. 23 November 2011. Hull Daily Mail, A Year of Chemistry in the Humber. pp 9.

Blogs and webpages

Regular contributor to Guardian Science blogs.

Regular contributor to The Conversation.

Lorch, M. Try this at home [blog] established February 2012.

Lorch, M. Chemistry-blog [blog] Staff blogger since March 2012.

Radio

Lorch, M. ‘Marketplace Tech’. American Public Media.  27 March 2013. Contribution: Interview on Hull’s contribution to LCDs 

Lorch, M. ‘You and Yours’. BBC Radio 4. 3 December 2012.  Contribution: Discussion on enzymes in washing powders.

Lorch, M ‘Andy Comfort’s Breakfast Show’. BBC Radio Humberside. 22 March 2013. 06:00 hrsContribution: Interview on Hull’s contribution to LCDs.

Lorch, M ‘James Hoggarth Show’ . BBC Radio Humberside. 16 March 2013. 10:00 hrsContribution: Interview on Science Week

Lorch, M ‘Andy Comfort’s Breakfast Show’. BBC Radio Humberside. 17th December 2012. 06:00hrs Contribution: Interview about Chemistry Christmas Lecture.

Lorch, M ‘Sunday Breakfast’. BBC Radio Humberside. 14 October 2012. 06:00hrsContribution: Discussion on science and religion.

Lorch, M. ‘Phil White Show’. BBC Radio Humberside. 29 May 2012. 14:00 hrs Contribution: Piece on science based play being delivered to primary schools in Hull and East Riding.

Lorch, M. ‘Roberto Perrone Show’. BBC Three Counties Radio. 21 March 2012. 15:00 hrs Contribution: Interview on Famelab and science communication.

Lorch, M. ‘Andy Comfort’s Breakfast Show’ .  20 March 2012. 06:00 hrs. Contribution: Interview on Famelab and science communication.

Lorch, M. ‘Carl Wheatley Show’. 10 March 2012. 06:00 hrs.Contribution: Interview on Science Week

 

Television

Lorch, M. Some Scientists Telling Jokes, BBC 4 (to be aired summer 2013). Contribution: I told some jokes!

Lorch M. Coast. Series 8 Episode 2, ‘The Worker’s Coast’ BBC 2. 10 April 2013. 20:00 hrs  Contribution: Demonstration and explanation of refrigeration in Grimsby ice factory.

Lorch M. ‘Look North’- Yorkshire, BBC 1. 23 March 2013. 18:30 hrs Contribution: Conversation about Hull’s contribution to LCDs.

Lorch M. ‘Points of View’  Commenting on James May’s Thing You Need to Know About Chemistry. BBC 2. 7 October 2012. 16:40hrs Contribution: Criticism of BBC chemistry program.

Lorch M. ‘Calendar TV‘   ITV. 14th June 2011. 18:30 hrs. Contribution: Interview on Children’s University visit to Chemistry Department.

Showreel

TV appearances

 

Radio interviews

Mark Lorch: Chemiphobia

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