Chemistry
School of Mathematics & Physical Sciences

Professor Steve J. Archibald

BSc (York), PhD (Edinburgh)

Dr Steve J. Archibald

Professor in Molecular Imaging Chemistry

Chemistry and Positron Emission Tomography Research Centre

  • Profile
  • Teaching
  • Research
  • Key publications

Profile

I was awarded a first class BSc degree at the University of York in Chemistry, Life Systems and Pharmaceuticals in 1992. I continued my studies at the University of Edinburgh under the supervision of Profs. Richard Winpenny and Martin Schroder and was awarded a PhD in 1995. I spent two years as a PDRA with Prof. Daryle Busch at the University of Kansas followed by a further two and a half years at the University of York in Prof. Paul Walton's laboratory. I was appointed as a Lecturer at the University of Hull in 2000, promoted to Senior Lecturer in 2008, Reader in 2011and Professor in 2014.

In 2013 I was appointed as the Director of the Positron Emission Tomography Research Centre at the University of Hull which became fully operational in summer 2014. This research facility carries out a range of studies spanning from isotope production to preclinical imaging. 

Departmental responsibilities

  • Member of Staff Student Committee  

University responsibilities

  • Director of the Positron Emission Tomography Research Committee
  • Chair of Radiation Hazards Sub-Committee
  • Chair of University/NHS/Daisy Appeal Scientific Committee for PET/CT Imaging 
  • Member of Faculty Board

Teaching

Lectures courses:

  • 06710/12/14 Bioinorganic and Medicinal Inorganic Chemistry
  • 06**** Descriptive Transition Metal Chemistry
  • 06**** Supramolecular Chemistry
  • 06**** Introduction to Bioinorganic Chemistry

Laboratory classes:

  • 3rd year Inorganic Laboratory (semester one)

Teaching interests:

  • Medical imaging science
  • Coordination chemistry
  • Bioinorganic chemistry
  • Supramolecular chemistry
  • Medicinal chemistry

Research

Research theme: Biological Chemistry
Research group: Biological Inorganic Chemistry

My research interests focus on radiopharmaceutical compounds for medical imaging and targeted protein binding molecules for therapeutic applications. My group is multi-disciplinary with expertise in synthesis, medical imaging techniques and biological assays.

Research interests

  • Radiopharmaceutical imaging (positron emission tomography)
  • Medicinal inorganic chemistry
  • Anti-viral compounds
  • Cancer therapeutics
  • Protein binding metal complexes

Key publications

  • Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, A. E. Sparke, C. M. Fisher, R. E. Mewis, and S. J. Archibald, Tetrahedron Lett., 2010, 51, 4723-6. doi: 10.1016/j.tetlet.2010.07.010
  • Biomedical applications of macrocyclic ligand complexes, R. E. Mewis and S. J. Archibald, Coord. Chem. Rev., 2010, 254, 1686-712. doi: 10.1016/j.ccr.2010.02.025
  • Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives, S. Jha, J. D. Silversides, R. W. Boyle, and S. J. Archibald, Crystengcomm, 2010, 12, 1730-9. doi: 10.1039/b924683e
  • A Cellular Screening Assay Using Analysis of Metal-Modified Fluorescence Lifetime, N. I. Cade, G. Fruhwirth, S. J. Archibald, T. Ng, and D. Richards, Biophys. J., 2010, 98, 2752-7. doi: 10.1016/j.bpj.2010.03.016

Full publication list

2010

  • Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, A. E. Sparke, C. M. Fisher, R. E. Mewis, and S. J. Archibald, Tetrahedron Lett., 2010, 51, 4723-6. doi: 10.1016/j.tetlet.2010.07.010
  • Biomedical applications of macrocyclic ligand complexes, R. E. Mewis and S. J. Archibald, Coord. Chem. Rev., 2010, 254, 1686-712. doi: 10.1016/j.ccr.2010.02.025
  • Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives, S. Jha, J. D. Silversides, R. W. Boyle, and S. J. Archibald, Crystengcomm, 2010, 12, 1730-9. doi: 10.1039/b924683e
  • A Cellular Screening Assay Using Analysis of Metal-Modified Fluorescence Lifetime, N. I. Cade, G. Fruhwirth, S. J. Archibald, T. Ng, and D. Richards, Biophys. J., 2010, 98, 2752-7. doi: 10.1016/j.bpj.2010.03.016

2009

  • Reductive Amination - A Convenient Method for Generating Diverse, Mono-Functionalised 5,10,15,20-Tetraphenyl Porphyrins, C. Welch, S. J. Archibald, and R. W. Boyle, Synthesis-Stuttgart, 2009, 551-6. doi: 10.1055/s-0028-1083335
  • Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: Effect of PEG chain length, coordinated metal, and axial ligand, R. E. Mewis, H. Savoie, S. J. Archibald, and R. W. Boyle, Photodiagnosis Photodyn. Ther., 2009, 6, 200-6. doi: 10.1016/j.pdpdt.2009.08.002
  • Synthesis and characterization of the chromium(III) complexes of ethylene cross-bridged cyclam and cyclen ligands, D. L. Maples, R. D. Maples, W. A. Hoffert, T. H. Parsell, A. van Asselt, J. D. Silversides, S. J. Archibald, and T. J. Hubin, Inorg. Chim. Acta, 2009, 362, 2084-8. doi: 10.1016/j.ica.2008.09.034
  • MRI contrast agent delivery using spore capsules: controlled release in blood plasma, M. Lorch, M. J. Thomasson, A. Diego-Taboada, S. Barrier, S. L. Atkin, G. Mackenzie, and S. J. Archibald, Chem. Commun., 2009, 6442-4. doi: 10.1039/b909551a
  • CXCR4 Antagonists: A New Generation of Configurationally Restricted Bis-azamacrocyclic Compounds, A. Khan, G. Nicholson, G. McRobbie, J. Greenman, C. Pannecouque, D. Daelemans, D. Schols, E. De Clercq, T. J. Hubin, and S. J. Archibald, Antiviral Res., 2009, 82, 136. doi: 10.1016/j.antiviral.2009.02.141
  • Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes, A. Khan, G. Nicholson, J. Greenman, L. Madden, G. McRobbie, C. Pannecouque, E. De Clercq, R. Ullom, D. L. Maples, R. D. Maples, J. D. Silversides, T. J. Hubin, and S. J. Archibald, J. Am. Chem. Soc., 2009, 131, 3416-+. doi: 10.1021/ja807921k
  • Preparation, structural characterization, and thermal ammonolysis of two novel dimeric transition metal silylamide complexes, F. Cheng, C. N. Hope, S. J. Archibald, J. S. Bradley, S. Clark, M. G. Francesconi, S. M. Kelly, N. A. Young, and F. Lefebvre, Int. J. Appld. Ceramic Technol., 2009, in press. doi: 10.1111/j.1744-7402.2009.02452.x
  • CXCR4 Chemokine Receptor Antagonists from Ultra-rigid Metal Complexes Profoundly Inhibit HIV-1 Replication, and also AMD3100-resistant Strains, S. J. Archibald, D. Daelemans, T. J. Hubin, D. Huskens, D. Schols, K. Van Laethem, E. De Clercq, and C. Pannecouque, Antiviral Res., 2009, 82, 95. doi: 10.1016/j.antiviral.2009.02.100

2008

  • Benz(2-heteroaryl) cyanoximes and their Tl(I) complexes: new room temperature blue emitters, O. T. Ilkun, S. J. Archibald, C. L. Barnes, N. Gerasimchuk, R. Biagioni, S. Silchenko, O. A. Gerasimchuk, V. N. Nemykin, and O. A. Gerasimchuke, Dalton Trans., 2008, 5715-29. doi: 10.1039/b803846e
  • The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions, D. L. Cockriel, J. M. McClain, K. C. Patel, R. Ullom, T. R. Hasley, S. J. Archibald, and T. J. Hubin, Inorg. Chem. Commun., 2008, 11, 1-4. doi: 10.1016/j.inoche.2007.10.006

2007

  • Copper(II) cyclam-based complexes for radiopharmaceutical applications: synthesis and structural analysis, J. D. Silversides, C. C. Allan, and S. J. Archibald, Dalton Trans., 2007, 971-8. doi: 10.1039/b615329a
  • Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists, G. McRobbie, G. C. Valks, C. J. Empson, A. Khan, J. D. Silversides, C. Pannecouque, E. De Clercq, S. G. Fiddy, A. J. Bridgeman, N. A. Young, and S. J. Archibald, Dalton Trans., 2007, 5008-18. doi: 10.1039/b705800d
  • Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists, G. McRobbie, G. C. Valks, C. J. Empson, A. Khan, J. D. Silversides, C. Pannecouque, E. De Clercq, S. G. Fiddy, A. J. Bridgeman, N. A. Young, and S. J. Archibald, Dalton Trans., 2007, 5008-18. doi: 10.1039/b705800d
  • Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding, A. Khan, J. D. Silversides, L. Madden, J. Greenman, and S. J. Archibald, Chem. Commun., 2007, 416-8. doi: 10.1039/b614557d
  • Small molecule CXCR4 chemokine candidates receptor antagonists: Developing drug candidates, A. Khan, J. Greenman, and S. J. Archibald, Curr. Med. Chem., 2007, 14, 2257-77. doi:
  • Isothiocyanato-calix[4]phyrin-(1,1,1,1): a useful intermediate for the synthesis of derivatised anion sensors, S. C. Jha, M. Lorch, R. A. Lewis, S. J. Archibald, and R. W. Boyle, Org. Biomol. Chem., 2007, 5, 1970-4. doi: 10.1039/b703646a
  • 3,4-Diiodo-2,5-dimethylthiophene, L. Cseh, G. H. Mehl, S. Clark, and S. J. Archibald, Acta Crystallogr. Sect. E.-Struct Rep. Online, 2007, 63, o1393-o4. doi: 10.1107/s160053680700760x

2007

  • Configurationally restricted bismacrocyclic CXCR4 receptor antagonists, G. C. Valks, G. McRobbie, E. A. Lewis, T. J. Hubin, T. M. Hunter, P. J. Sadler, C. Pannecouque, E. De Clercq, and S. J. Archibald, J. Med. Chem., 2006, 49, 6162-5. doi: 10.1021/jm0607810
  • N-(4-nitrobenzyl)benzene-1,2-diamine, J. D. Silversides, A. E. Sparke, and S. J. Archibald, Acta Crystallogr. Sect. E.-Struct Rep. Online, 2006, 62, O5944-O6. doi: 10.1107/s1600536806050136
  • Routes to highly substituted thiophenol derivatives, G. Nicholson, J. D. Silversides, and S. J. Archibald, Tetrahedron Lett., 2006, 47, 6541-4. doi: 10.1016/j.tetlet.2006.07.039
  • (N-benzyl-bis-N ',N ''-salicylidene)-cis-1,3,5-triaminocyclohexane copper(II): a novel catalyst for the aerobic oxidation of benzyl alcohol, A. K. Nairn, S. J. Archibald, R. Bhalla, B. C. Gilbert, E. J. MacLean, S. J. Teat, and P. H. Walton, Dalton Trans., 2006, 172-6. doi: 10.1039/b512296c
  • Syntheses of copper(I) cis-1,3,5-tri-iminocyclohexane complexes, A. K. Nairn, S. J. Archibald, R. Bhalla, C. J. Boxwell, A. C. Whitwood, and P. H. Walton, Dalton Trans., 2006, 1790-5. doi: 10.1039/b510703b
  • Dichloro(4,10-dimethyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane)iron(I II) hexafluorophosphate, J. M. McClain, D. L. Maples, R. D. Maples, D. L. Matz, S. M. Harris, A. D. L. Nelson, J. D. Silversides, S. J. Archibald, and T. J. Hubin, Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 2006, 62, M553-M5. doi: 10.1107/s0108270106040765

2005

  • Toward the soil poultice and a new separations methodology: Rebinding of macrocyclic metal complexes to molecularly imprinted polymers specifically templated via noncovalent interactions, X. Zuo, D. Mosha, S. J. Archibald, A. K. McCasland, A. M. Hassan, R. S. Givens, and D. H. Busch, J. Coord. Chem., 2005, 58, 21-39. doi: 10.1080/00958970512331327357
  • Novel amide-based chain transfer agent for reversible addition fragmentation chain transfer polymerization, P. Takolpuckdee, C. A. Mars, S. Perrier, and S. J. Archibald, Macromolecules, 2005, 38, 1057-60. doi: 10.1021/ma048727l
  • Configurationally restricted bis-azamacrocycles: chemokine receptor antagonists, A. Khan, G. McRobbie, L. A. Madden, C. J. Empson, A. J. Bridgeman, R. Ullom, T. J. Hubin, J. Greenman, and S. J. Archibald, Immunology, 2005, 116, 75-. doi:
  • Ammonothermal synthesis of a mesoporous Si-Ti-N composite material from a single-source precursor, F. Cheng, S. M. Kelly, S. Clark, N. A. Young, S. J. Archibald, J. S. Bradley, and F. Lefebvre, Chem. Mater., 2005, 17, 5594-602. doi: 10.1021/cm051401m
  • Ammonothermal synthesis of a mesoporous si-ti-n composite material from a single-source precursor, F. Cheng, S. M. Kelly, S. Clark, N. A. Young, S. J. Archibald, J. S. Bradley, and F. Lefebvre, Chem. Mater., 2005, 17, 5594-602. doi: 10.1021/cm051401m
  • Synthesis and structure of tetrakis(isopropylimino)bis-[tris(dimethylamino)silylamino]alane, F. Cheng, S. Clark, S. J. Archibald, S. M. Kelly, and J. S. Bradley, J. Organomet. Chem., 2005, 690, 1205-8. doi: 10.1016/j.jorganchem.2004.11.025
  • C-F Bond activation at Ni(0) and simple reactions of square planar Ni(II) fluoride complexes, S. Burling, P. I. P. Elliott, N. A. Jasim, R. J. Lindup, J. McKenna, R. N. Perutz, S. J. Archibald, and A. C. Whitwood, Dalton Trans., 2005, 3686-95. doi: 10.1039/b510052f
  • Mono-benzyl substituted cis, cis-1,3,5-triaminocyclohexanes, S. J. Archibald, A. K. Nairn, P. Timmins, and P. H. Walton, Tetrahedron Lett., 2005, 46, 6441-3. doi: 10.1016/j.tetlet.2005.07.112

2004

  • Synthesis and structural characterisation of novel bimetallic dipyrromethene complexes: rotational locking of the 5-aryl group, J. M. Sutton, E. Rogerson, C. J. Wilson, A. E. Sparke, S. J. Archibald, and R. W. Boyle, Chem. Commun., 2004, 1328-9. doi: 10.1039/b404147j
  • Rigidity extremes in coordination chemistry: a fine energetic balance in the isolation of a trapped ligand inversion intermediate, C. M. May, S. J. Archibald, A. J. Bridgeman, C. J. Empson, and T. J. Hubin, Chem. Commun., 2004, 1880-1. doi: 10.1039/b405358c
  • Synthesis and characterization of the cobalt(III) complexes of two pendant-arm cross-bridged cyclams, J. Lichty, S. M. Allen, A. I. Grillo, S. J. Archibald, and T. J. Hubin, Inorg. Chim. Acta, 2004, 357, 615-8. doi: 10.1016/j.ica.2003.08.014
  • Ultrastable complexes for in vivo use: a bifunctional chelator incorporating a cross-bridged macrocycle, E. A. Lewis, R. W. Boyle, and S. J. Archibald, Chem. Commun., 2004, 2212-3. doi: 10.1039/b406906d
  • Efficient N- and C-functionalisation of cyclam macrocycles utilising bisaminal methodology, E. A. Lewis, C. C. Allan, R. W. Boyle, and S. J. Archibald, Tetrahedron Lett., 2004, 45, 3059-62. doi: 10.1016/j.tetlet.2004.02.108

2003

  • Replacement of [RuH2(PMe3)(4)] by [RuH2(PEt3)(4)] switches reaction products: synthesis of fluoride-bridged diruthenium complexes, N. A. Jasim, R. N. Perutz, and S. J. Archibald, Dalton Trans., 2003, 2184-7. doi: 10.1039/b301582c
  • Preparation of mesoporous silicon boron imide gels from single-source precursors via a nonaqueous sol-gel route, F. Cheng, S. J. Archibald, S. Clark, B. Toury, S. M. Kelly, J. S. Bradley, and F. Lefebvre, Chem. Mater., 2003, 15, 4651-7. doi:
  • Syntheses and structures of [(Me3N)(3)SiNHLi](4), (C4H8O)Al[NHSi(NMe2)(3)](3), ((Me2N)(3)SiNH)(3)Al and Li(THF)(2)(+)[((Me2N)(3)SiNH) Al-4](-), J. S. Bradley, F. Cheng, S. J. Archibald, R. Supplit, R. Rovai, C. W. Lehmann, C. Kruger, and F. Lefebvre, Dalton Trans., 2003, 1846-51. doi: 10.1039/b209605f
  • On the sulfimidation of benzo[b]thiophene, S. J. Archibald, A. N. Boa, and N. Pesa, Chem. Commun., 2003, 1736-7. doi: 10.1039/b304696f
  • Rigid tetraazamacrocycle copper complexes: Radiopharmaceutical applications, C. C. Allan, S. J. Archibald, J. D. Silversides, and E. A. Lewis, J. Inorg. Biochem., 2003, 96, 91-. doi:
  • A silver-iodine chain complex: catena-poly[anilinium [silver(I)-di-mu-iodo]], {[PhNH3][Agl(2)]}n, N. W. Alcock, S. J. Archibald, and D. H. Busch, Acta Crystallogr. Sect. E.-Struct Rep. Online, 2003, 59, M1110-M1. doi: 10.1107/s1600536803024966

2002

  • Synthesis and structure of 2,4,6-tris[tris(dimethylamino)silylamino]borazine: {[(CH3)(2)N](3)SiNH}(3)B3N3H3, F. Cheng, B. Toury, S. J. Archibald, and J. S. Bradley, J. Organomet. Chem., 2002, 657, 71-4. doi:
  • Preparation of cationic cobalt phenoxide and ethoxide complexes and their reversible reaction with carbon dioxide, S. J. Archibald, S. P. Foxon, J. D. Freeman, J. E. Hobson, R. N. Perutz, and P. H. Walton, J. Chem. Soc., Dalton Trans., 2002, 2797-9. doi: 10.1039/b204560e

2001

  • Towards functional mimics of manganese superoxide dismutases, E. A. Lewis, J. R. L. Smith, P. H. Walton, H. Khodr, R. C. Hider, S. J. Archibald, and G. M. Giblin, J. Inorg. Biochem., 2001, 86, 315-. doi:
  • Tuning the metal-based redox potentials of manganese cis,cis-1,3,5-triaminocyclohexane complexes, E. A. Lewis, J. R. L. Smith, P. H. Walton, S. J. Archibald, S. P. Foxon, and G. M. P. Giblin, J. Chem. Soc., Dalton Trans., 2001, 1159-61. doi: 10.1039/b102103f
  • Nickel thiophenolate complexes: can a stable bound thiyl radical be formed?, S. J. Archibald and K. Bradley, J. Inorg. Biochem., 2001, 86, 128-. doi:

2000

  • A novel route to preussomerins via 2-arylacetal anions, J. P. Ragot, M. E. Prime, S. J. Archibald, and R. J. K. Taylor, Org. Lett., 2000, 2, 1613-6. doi:
  • Hydrogen bonding interactions in amorphous salicyl salicylate, B. Greener, S. J. Archibald, and M. Hodkinson, Angew. Chem. Int. Edit., 2000, 39, 3601-4. doi:
  • Chemistry of nickel tetrafluoropyridyl derivatives: their versatile behaviour with Bronsted acids and the Lewis acid BF3, S. J. Archibald, T. Braun, J. A. Gaunt, J. E. Hobson, and R. N. Perutz, J. Chem. Soc., Dalton Trans., 2000, 2013-8. doi:
  • Synthesis and characterization of silver(I) complexes with C-alkyl functionalized N,N '-diphenylamidinates: Tetrameric and trimeric structural motifs, S. J. Archibald, N. W. Alcock, D. H. Busch, and D. R. Whitcomb, J. Cluster Sci., 2000, 11, 261-83. doi:

1999

  • New ligands for modelling secondary interactions in the active site of carbonic anhydrase, S. J. Archibald, A. M. Harris, and P. H. Walton, J. Inorg. Biochem., 1999, 74, 67-. doi:
  • Synthesis and characterization of functionalized N,N '-diphenylformamidinate silver(I) dimers: Solid-state structures and solution properties, S. J. Archibald, N. W. Alcock, D. H. Busch, and D. R. Whitcomb, Inorg. Chem., 1999, 38, 5571-8. doi:

1997

  • Lanthanoid complexes of a tripodal acetal ligand: Synthesis, structural characterisation and reactivity with 3d metals, S. J. Archibald, A. J. Blake, S. Parsons, M. Schroder, and R. E. P. Winpenny, J. Chem. Soc., Dalton Trans., 1997, 173-9. doi:

1994

  • New Ligands for Complexation of Lanthanoids - the Synthesis and Structures of a Nonadentate Schiff-Base Ligand (L(1)) and of the Complexes [Ml(1)(Oh2)](Clo4)(3).3meno(2) (M=La, Pr) and [Yl(1)](Clo4)(3)Center-Dot-3mecn, S. J. Archibald, A. J. Blake, M. Schroder, and R. E. P. Winpenny, J. Chem. Soc., Chem. Commun., 1994, 1669-70. doi:
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