School of Engineering

Medical and Biological Engineering Research Group

Welcome ...

The MBE Group’s expertise lies in modelling and simulation in biomechanics and biomedical engineering applied in particular to understand the mechanobiology of bone and its use in predictive biology.

This includes: (1) at the cellular level – modelling of the osteocyte network and its control of the mechanotransduction, and modelling of the bone remodelling cycle; (2) at the tissue level – modelling the differentiation and growth of bone into scaffolds and the osseointegration of orthopaedic implants; and (3) at the organ level – modelling the biomechanics of skulls, including various primate, lizard, pig, sheep, rabbit and rodent skulls. See our research pages.

The long term goal of the work is to develop a fully integrated multiscale model of bone. As part of that work we are developing our own voxel-based finite element software VOX-FE, for the analysis of very large-scale, high-resolution models of bone structures.

Current and recent supporters of our research include Action Medical Research, BBSRC, Department of Health, EPSRC, Leverhulme, MRC, NERC, OSPREY, the Royal Academy of Engineering and the Royal Society.

Our next seminar

See Seminars.

Latest publications

  • B Ji, R Patton, P Genever, D Putra, MJ Fagan. 2014. Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease. International Journal for Numerical Methods in Biomedical Engineering – in press. LINK (open access)
  • Porro LB, Ross CF, Iriarte-Diaz J, O'Reilly JC, Evans SE, Fagan MJ. 2014. In vivo cranial bone strain and bite force in the agamid lizard Uromastyx geyri. Journal of Experimental Biology – in press. LINK (open access)
  • N Curtis, U Witzel, MJ Fagan. 2014. Development and 3D morphology of the zygomatico-temporal suture in primate skulls. Folia Primatologica, 85: 77-87. LINK (open access)  + open access supplementary information
  • G Gosselin, MJ Fagan. 2014. Effects of cervical muscle fatigue on the perception of the subjective vertical and horizontal. Accepted for publication: SpringerPlus (Biomedical and Life Sciences) 3:78. LINK (open access)
  • G Gosselin, MJ Fagan. 2014. The effects of cervical muscle fatigue on balance – a study with elite amateur rugby league players. Journal of Sports Science & Medicine 13:2 329-337 – in press. LINK (open access)
  • N Curtis, MEH Jones, SE Evans, P O’Higgins, MJ Fagan. 2013. Cranial sutures work collectively to distribute strain throughout the reptile skull. Journal of the Royal Society Interface - in press. LINK (open access)
  • F Gröning, MEH Jones, N Curtis, A Herrel, P O’Higgins, SE. Evans, MJ. Fagan. 2013. The importance of accurate muscle modelling for biomechanical analyses: a case study with a lizard skull. Journal of the Royal Society Interface - in press. LINK (open access)
  • F Gröning, MJ Fagan, P O’Higgins. Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study. Anatomical Record, 296:1, 9-18, 2013. LINK
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