Medical and Biological Engineering Research Group
Last updated on 5/28/2014 Print this page
The MBE Group’s expertise lies in modelling and simulation
in biomechanics and biomedical engineering applied in particular to
understand the mechanobiology of bone and its use in predictive
This includes: (1) at the cellular level – modelling of the
osteocyte network and its control of the mechanotransduction, and
modelling of the bone remodelling cycle; (2) at the tissue level –
modelling the differentiation and growth of bone into scaffolds and
the osseointegration of orthopaedic implants; and (3) at the organ
level – modelling the biomechanics of skulls, including various
primate, lizard, pig, sheep, rabbit and rodent skulls. See our
The long term goal of the work is to develop a fully integrated
multiscale model of bone. As part of that work we are developing
our own voxel-based finite element software VOX-FE, for the analysis
of very large-scale, high-resolution models of bone structures.
Current and recent supporters of our research include
Action Medical Research, BBSRC,
Department of Health, EPSRC,
NERC, OSPREY, the Royal Academy of
Engineering and the Royal
Our next seminar
- B Ji, R Patton, P Genever, D Putra, MJ Fagan. 2014.
Mathematical modelling of the pathogenesis of multiple
myeloma-induced bone disease. International Journal for Numerical
Methods in Biomedical Engineering – in press. LINK (open
- Porro LB, Ross CF, Iriarte-Diaz J, O'Reilly JC, Evans SE,
Fagan MJ. 2014. In vivo cranial bone strain and bite force in the
agamid lizard Uromastyx geyri. Journal of Experimental Biology – in
press. LINK (open
- N Curtis, U Witzel, MJ Fagan. 2014. Development and 3D
morphology of the zygomatico-temporal suture in primate
skulls. Folia Primatologica, 85: 77-87. LINK (open
open access supplementary information
- G Gosselin, MJ Fagan. 2014. Effects of cervical muscle fatigue
on the perception of the subjective vertical and horizontal.
Accepted for publication: SpringerPlus (Biomedical and Life
Sciences) 3:78. LINK (open
- G Gosselin, MJ Fagan. 2014. The effects of cervical muscle
fatigue on balance – a study with elite amateur rugby league
players. Journal of Sports Science & Medicine 13:2 329-337 – in
LINK (open access)
- N Curtis, MEH Jones, SE Evans, P O’Higgins, MJ Fagan. 2013.
Cranial sutures work collectively to distribute strain throughout
the reptile skull. Journal of the Royal Society Interface - in
press. LINK (open
- F Gröning, MEH Jones, N Curtis, A Herrel, P O’Higgins, SE.
Evans, MJ. Fagan. 2013. The importance of accurate muscle modelling
for biomechanical analyses: a case study with a lizard
skull. Journal of the Royal Society Interface - in press.
- F Gröning, MJ Fagan, P O’Higgins. Comparing the distribution of
strains with the distribution of bone tissue in a human mandible: a
finite element study. Anatomical Record, 296:1, 9-18, 2013.