Medical and Biological Engineering Research Group
Last updated on 1/30/2014 Print this page
The MBE Group’s expertise lies in modelling and simulation
in biomechanics and biomedical engineering applied in particular to
understand the mechanobiology of bone and its use in predictive
This includes: (1) at the cellular level – modelling of the
osteocyte network and its control of the mechanotransduction, and
modelling of the bone remodelling cycle; (2) at the tissue level –
modelling the differentiation and growth of bone into scaffolds and
the osseointegration of orthopaedic implants; and (3) at the organ
level – modelling the biomechanics of skulls, including various
primate, lizard, pig, sheep, rabbit and rodent skulls. See our
The long term goal of the work is to develop a fully integrated
multiscale model of bone. As part of that work we are developing
our own voxel-based finite element software VOX-FE, for the analysis
of very large-scale, high-resolution models of bone structures.
Current and recent supporters of our research include
Action Medical Research, BBSRC,
Department of Health, EPSRC,
NERC, OSPREY, the Royal Academy of
Engineering and the Royal
Our next seminar
Dr Yang Liu (Wolfson School of Mechanical and
Manufacturing Engineering, Loughborough
Enabling tools for
realisation of tissue engineering and regenerative medicine
technology: from an engineering
Monday 17 February
(For details, see Seminars).
- N Curtis, U Witzel, MJ Fagan. 2014. Development and 3D
morphology of the zygomaticotemporal suture in primate
skulls. Folia Primatologica, 85: 77-87. LINK +
open access supplementary information
- N Curtis, MEH Jones, SE Evans, P O’Higgins, MJ Fagan. 2013.
Cranial sutures work collectively to distribute strain throughout
the reptile skull. Journal of the Royal Society Interface - in
press. LINK (open
- F Gröning, MEH Jones, N Curtis, A Herrel, P O’Higgins, SE.
Evans, MJ. Fagan. 2013. The importance of accurate muscle modelling
for biomechanical analyses: a case study with a lizard
skull. Journal of the Royal Society Interface - in press.
- F Gröning, MJ Fagan, P O’Higgins. Comparing the distribution of
strains with the distribution of bone tissue in a human mandible: a
finite element study. Anatomical Record, 296:1, 9-18, 2013.
- Jahani, F Ahwal, B Ji, R Patton, P Genever, MJ Fagan.
Simulation of osteocyte apoptosis on signalling in the
osteocyte-bone lining cell network and implications for
osteoporosis. Journal of Biomechanics. 45:16, 2876-83, 2012.
- J Shi, N Curtis, LC Fitton, P O'Higgins, MJ Fagan. Developing a
musculoskeletal model of the primate skull: predicting muscle
activations, bite force, and joint reaction forces using multibody
dynamics analysis and advanced optimisation methods. Journal
Journal of Theoretical Biology, 310, 21-30, 2012. LINK
- MEH Jones, P O’Higgins, MJ Fagan, SE Evans, N Curtis. Shearing
mechanics and the influence of a flexible symphysis during oral
food processing in Sphenodon (Lepidosauria:
Rhynchocephalia). Anatomical Record, 295:7, 1075-1091, 2012.
- B Ji, R Patton, P Genever, D Putra, MJ Fagan. A novel
mathematical model of bone remodelling cycles for trabecular bone
at the cellular level. Biomechanics and Modelling in
Mechanobiology. 11:7, 973-982, 2012. LINK