Medical and Biological Engineering Research Group
Last updated on 10/30/2015 Print this page
The MBE Group’s expertise lies in modelling and simulation
in biomechanics and biomedical engineering applied in particular to
understand the mechanobiology of bone, and use of those techniques
in predictive biology.
This includes: (1) at the cellular level – modelling of the
osteocyte network and its control of the
mechanotransduction, modelling of the bone remodelling cycle
and modelling of bone diseases; (2) at the tissue level –
modelling the basic (re)modelling processes of bone, and modelling
the effect of changes in musculoskeletal function on osteoporosis
and in Perthes’ disease; and (3) at the organ level –
modelling the biomechanics of skulls, including various primate,
lizard, pig, sheep, rabbit and rodent skulls. See our
The long term goal of the work is to develop a fully integrated
multiscale model of bone. As part of that work we are developing
our own voxel-based finite element software VOX-FE, for the analysis
of very large-scale, high-resolution models of bone structures.
Current and recent supporters of our research include
Action Medical Research, BBSRC,
Department of Health, EPSRC,
NERC, OSPREY, the Royal Academy of
Engineering and the Royal
In the recent REF2014 exercise, over 85% of our publications
were judged to be 'world leading' or 'internationally
- M Moazen, E Peskett, C Babbs, E Pauws, MJ Fagan.
Mechanical properties of calvarial bones in a mouse model for
craniosynostosis. PLoS ONE 10:5: e0125757. LINK (open
- PJ Watson, MJ Fagan, CA Dobson. 2015. Sensitivity
to model geometry in finite element analyses of reconstructed
skeletal structures: Experience with a juvenile pelvis. Journal of
engineering in Medicine, 229:1, 9-19. LINK (open
- G Gosselin, MJ Fagan. 2015. Foam pads properties
and their effects on posturography in participants of different
weight. Chiropractic & Manual Therapies 23:2.
- B Ji, Q Yang, P Genever, MJ Fagan. 2014.
Investigating the efficacy of bisphosphonates treatment against
multiple myeloma induced bone disease using a computational model.
Bio-Medical Materials and Engineering 24:6, 3373-3378.
- PJ Watson, F Gröning, N Curtis, L Fitton, A Herrel, S
McCormack, MJ Fagan. 2014. Multi-body dynamics modelling of the
rabbit skull. Journal of the Royal Society Interface 6:11,
20140564. LINK (open
- SW McCormack, U Witzel, PJ Watson, MJ Fagan, F Gröning.
2014. The biomechanical function of periodontal ligament fibres in
orthodontic tooth movement. PLoS One 9:7 e102387. LINK (open
- B Ji, R Patton, P Genever, D Putra, MJ Fagan. 2014.
Mathematical modelling of the pathogenesis of multiple
myeloma-induced bone disease. International Journal for Numerical
Methods in Biomedical Engineering – in press. LINK (open
- Porro LB, Ross CF, Iriarte-Diaz J, O'Reilly JC, Evans SE,
Fagan MJ. 2014. In vivo cranial bone strain and bite force in the
agamid lizard Uromastyx geyri. Journal of Experimental Biology
217, 1983-92. LINK (open
- N Curtis, U Witzel, MJ Fagan. 2014. Development and 3D
morphology of the zygomatico-temporal suture in primate
skulls. Folia Primatologica, 85: 77-87. LINK (open
open access supplementary information