School of Engineering

Medical and Biological Engineering Research Group

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Welcome ...

The MBE Group’s expertise lies in modelling and simulation in biomechanics and biomedical engineering applied in particular to understand the mechanobiology of bone and its use in predictive biology.

This includes: (1) at the cellular level – modelling of the osteocyte network and its control of the mechanotransduction, and modelling of the bone remodelling cycle; (2) at the tissue level – modelling the differentiation and growth of bone into scaffolds and the osseointegration of orthopaedic implants; and (3) at the organ level – modelling the biomechanics of skulls, including various primate, lizard, pig, sheep, rabbit and rodent skulls. See our research pages.

The long term goal of the work is to develop a fully integrated multiscale model of bone. As part of that work we are developing our own voxel-based finite element software VOX-FE, for the analysis of very large-scale, high-resolution models of bone structures.

Current and recent supporters of our research include Action Medical Research, BBSRC, Department of Health, EPSRC, Leverhulme, MRC, NERC, OSPREY, the Royal Academy of Engineering and the Royal Society.
 

Our next seminar

Dr Yang Liu (Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University)
Enabling tools for realisation of tissue engineering and regenerative medicine technology: from an engineering perspective
Monday 17 February  (For details, see Seminars).
 

Latest publications

  • N Curtis, U Witzel, MJ Fagan. 2014. Development and 3D morphology of the zygomaticotemporal suture in primate skulls. Folia Primatologica, 85: 77-87. LINK + open access supplementary information
  • N Curtis, MEH Jones, SE Evans, P O’Higgins, MJ Fagan. 2013. Cranial sutures work collectively to distribute strain throughout the reptile skull. Journal of the Royal Society Interface - in press. LINK (open access)
  • F Gröning, MEH Jones, N Curtis, A Herrel, P O’Higgins, SE. Evans, MJ. Fagan. 2013. The importance of accurate muscle modelling for biomechanical analyses: a case study with a lizard skull. Journal of the Royal Society Interface - in press. LINK (open access)
  • F Gröning, MJ Fagan, P O’Higgins. Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study. Anatomical Record, 296:1, 9-18, 2013. LINK
  • Jahani, F Ahwal, B Ji, R Patton, P Genever, MJ Fagan. Simulation of osteocyte apoptosis on signalling in the osteocyte-bone lining cell network and implications for osteoporosis. Journal of Biomechanics. 45:16, 2876-83, 2012. LINK
  • J Shi, N Curtis, LC Fitton, P O'Higgins, MJ Fagan. Developing a musculoskeletal model of the primate skull: predicting muscle activations, bite force, and joint reaction forces using multibody dynamics analysis and advanced optimisation methods. Journal Journal of Theoretical Biology, 310, 21-30, 2012. LINK
  • MEH Jones, P O’Higgins, MJ Fagan, SE Evans, N Curtis. Shearing mechanics and the influence of a flexible symphysis during oral food processing in Sphenodon (Lepidosauria: Rhynchocephalia). Anatomical Record, 295:7, 1075-1091, 2012. LINK
  • B Ji, R Patton, P Genever, D Putra, MJ Fagan. A novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level. Biomechanics and Modelling in Mechanobiology. 11:7, 973-982, 2012. LINK
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